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It
has been shown that FGF10 has a significant role in the
branching morphogenesis in the embryonic mouse lung
(Bellusci
et al., 1997; Weaver et al.,
2000). During embryonic mouse lung morphogenesis, the distal
mesenchyme regulates the growth and
branching of adjacent
endoderm. It was reported that Fibroblast Growth Factor 10
(FGF10) is expressed dynamically in the
mesenchyme adjacent to the
distal buds from the earliest stages of lung development
(Bellusci et al., 1997). Results from out
experiment suggest that
FGF10 acts in the same role in embryonic chick lungs as it
does in mice development. By using an
FGF10 inhibitor on 6-day-old
chick lungs we observed that formation of further lung buds
does not occur as it normally would.
By using FGF10 loaded
heparin beads we were able to induce the production of new
lung buds in 6-day-old chick embryos.
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