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Objective
The purpose of this investigation is to test the
teratogenic effects of pentavalent arsenic, in the form of
sodium arsenate, on the development of zebrafish (Danio
rerio) embryos. Embryos will be incubated in varying
concentrations of arsenic (V) and observed periodically to
determine what, if any, are the morphological defects
present in arsenic-treated embryos. We will first attempt to
establish an effective range of arsenic concentration on
zebrafish embryo development. Based on previous experimental
evidence concerning the teratogenic and toxic effects of
arsenic, we will focus the second part of the investigation
on observing neural tube malformation and embryo
mortality.
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