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Introduction
Lead is a transition
metal that is sometimes found in drinking water of chicks
and animals. Lead interferes with genes that affect the cell
signaling pathways during neural development, such as Pax
transcription factors and FGF-8, a paracrine factor. These
factors are critically important in establishing the
boundaries of the fore-, mid-, and hind- brain (Gilbert,
2000). Anwer et al. (Anwer, 1988) experimented with the
effects of lead and zinc on developing chick embryos. They
injected the yolk sac of 7-day-old chicks with 50ug of lead
acetate dissolved in water. The embryos were removed from
the eggshell on the twenty-first day of incubation. They
found the chicks to be deformed in beak, legs, and body.
They also found incidents of hydrocephalus, microphthalmia,
and anophthalmia.
Joanna Burger (Burger, 1995)
performed a risk assessment for behavioral and physical
effects of lead on adult birds. Burger cited research by De
Franciscis and Boccalatter, who concluded that there is a
relationship between lead exposure and body weight of
embryos. They demonstrated that increasing levels of lead
caused a decrease in the body weight of chick embryos. Lead
exposed chick embryos showed meningocele, cranioschisis, and
hydrocephalus. Burger also found many deformities in birds,
including one that may be particularly pertinent to our
experiment. She found a significant difference in brain
weight of barn swallows exposed to lead opposed to those not
exposed to lead.
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