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Those are things that shouldbe allowed to cross the membrane.

Q. But should the membrane be porous like a sieve?
What kinds of things should notbe allowed to cross membranes? - basically the cell contents

Q. What kind of structure can satisfy all these requirements? Small, uncharged molecules pass freely
Specific large and/or charged molecules pass only with help

B. Basics of membrane structure8.5 There may be other solutions, but let's look at the solution to this problem that evolved on this planet.

Fig 8.5This is a cartoon of an animal cell's plasma membrane. Q. What would be different if it was a plant cell?
- only the extracellular matrix/cell wall

The basic concept of the plasma membrane is that of protein "icebergs" floating in a "sea" of lipids. This is known as the Fluid Mosaic Model.

The 2 components (lipids and proteins) both play a role in permeability

1. The lipid bilayer is amphipathic8.1 The lipid bilayeris made up of lipid molecules containing long hydrocarbon chains (hydrophobic) connected to a charged head group (hydrophilic), which makes it amphipathic. The bilayer provides a barrier to large and charged molecules, which cannot pass through the hydrophobic region.

IMAGE imgs/220C_05Lecture02.gif

2. Diffusion8.9, 8.10 Only small, uncharged molecules such as O2and H2O can cross These molecules are moving by diffusion, the movement of substances from regions of higher concentration towards regions of lower concentration.